Sunday features 20 teams in action, which means numerous ways to bet on the Premier League with Nottingham Forest and Chelsea's contest leading in importance.
Danny Welbeck has double-digit Premier League goals for the first time in his career and still may go under the radar for Sunday's 10-game DFS slate at FanDuel.
A big question for Sunday's match against Everton is the status of Alexander Isak, but even if he doesn't start, Newcastle have the edge playing at St. James' Park.
Ollie Watkins will be the focus and most likely goalscorer of Aston Villa's attack in a must-win match against Manchester United on Sunday.
It only makes sense to bet on Kevin De Bruyne in his final match in a Manchester City kit. They travel to Fulham on Sunday with Champions League still in the balance.
Nottingham Forest will try to ride their home crowd at City Ground in a must-win matchup against Chelsea with both teams vying for Champions League qualification.
Hirving Lozano has four goals and four assists this season and figures to be a useful card for Sorare's West Coast Clash competition celebrating MLS's 30th year.
If Arsenal play a strong XI against Southampton, it'll be hard to fade certain Gunners for Sunday's 10-game DraftKings DFS slate, especially Bukayo Saka.
Brajan Gruda seems set for another start and is widely available at Fantrax and Sleeper, making him one of the best waiver wire options ahead of Gameweek 38.
Bournemouth are one of the biggest favorites in Gameweek 38 and a few of their players like Kepa Arrizabalaga could be key FPL differentials for Sunday's finale.
Bournemouth are the biggest favorite in Gameweek 38, and with a slim bench, starters like Justin Kluivert should be top options for Fantrax and Sleeper managers.
Erling Haaland should have an easier time finding the back of the net against Bournemouth on Tuesday in what expects to be a much different match than the FA Cup final.
The best FPL strategy in Gameweek 38 will be to target favored teams in need of points, which means Newcastle and Anthony Gordon at home against post-Goodison Everton.
Brentford are rolling to close the season and will aim for another three points against Fulham on Sunday in their quest to finish in the Premier League's top eight.
Adam Zdroik and Chris Owen bet on the penultimate gameweek of the 2024/25 Premier League season, featuring Newcastle traveling to Arsenal on Sunday.
Crystal Palace found ways to score in their last meeting with Manchester City and Eberechi Eze will be looking for similar success in Saturday's FA Cup final.
Aston Villa and Chelsea are fighting for Champions League spots and are seemingly the best places to target in DFS ahead of Friday's two-game slate at DraftKings.
Cole Palmer hasn't been at his best lately, but in a possibly more forward role against Manchester United, he should rack up plenty of shots in Friday's key match.