The Latest Bills Odds For NFL Season 2025
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Buffalo Bills
0-0 (0-0 in the AFC East)
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Bills Week 1 Matchup
Sunday at 8:20 pm EST
Baltimore Ravens
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Buffalo Bills
Moneyline
DraftKings Spread
DraftKings Over Under
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Projected Record: 16-1 (6-0 AFC East)
Win Totals
DraftKings Wins
PROBABILITY with vig removed
Over 11.5 Wins(-160)
59.1%
Under 11.5 Wins(135)
40.9%
LINE MOVEMENT
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Super Bowl
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AFC Champ
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AFC East
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Bills Injury Report
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Bills News
QB
Shane Buechele: Participating in OTAs
May 28th
Buechele (neck) participated during OTAs on Tuesday.
DE
Joey Bosa: Dealing with calf issue
May 27th
Coach Sean McDermott said Tuesday that Bosa will not participate in offseason workouts this spring due to a calf injury, Jay Skurski of The Buffalo News reports.
RB
James Cook: Not at voluntary OTAs
May 27th
Cook wasn't present for Tuesday's voluntary organized team activities, Alaina Getzenberg of ESPN reports.
WR
Kristian Wilkerson: Signs with Buffalo
May 19th
Wilkerson signed with the Bills on Monday, Aaron Wilson of KPRC 2 Houston reports.
DT
Deone Walker: Healthy in rookie camp
May 10th
Walker, who is in rookie camp this week, revealed that he played the 2024 season with a back injury, Alec White and Maddy Glab of the Bills' official site report. "I had a pars defect in my back," Walker said on the night of the 2025 NFL Draft. "I didn't know about it until after the season, really until the combine. We didn't really know what it was, but I feel a 100 percent right now."
Bills Depth Chart
Quarterback QB
Running Back RB
Wide Receiver WR
Tight End TE
Fullback FB