In a marquee matchup with CC Sabathia, Johan Santana will be looking to recapture some of his old magic against the Yankees.
Tim Lincecum has had his ups and downs this year, but he's back atop the value meter with two starts this week.
Interleague play brings a lot of new matchups, but not for Albert Pujols and the Cardinals, who have plenty of history with Oakland starter Ben Sheets.
Ian Kinsler loves to face Houston's Wandy Rodriguez (9-for-12, 2 HR) and he'll get to face him again on Friday.
Pirates top prospect Pedro Alvarez was called up for his big league debut on Wednesday night. Do Pirates fans now have more to be excited about than Primanti's?
Justin Verlander and the Tigers host the Nats on Wednesday, but they won't get a crack at Stephen Strasburg.
Johan Santana managed just one strikeout in his last outing, but he has fond memories of fanning Cleveland hitters with regularity.
Albert Pujols must have been sad to see Ian Snell traded to Seattle last season, but thanks to interleague play he will face him again on Monday.