Michael Penix is unproven, but the quarterback change gives new hope to Falcons pass catchers like Drake London.
Ever since Marshon Lattimore switched teams, Washington's Week 15 matchup with New Orleans became a good matchup for Terry McLaurin.
Terry McLaurin should stay hot against a Titans defense starting its third- and fourth-string corners on the boundary.
The Ravens might want to shadow George Pickens with Marlon Humphrey, because the other Ravens corners can't cover Pickens.
Justin Jefferson will almost certainly have a big game Sunday, and the Colts pass defense is weak enough for Jordan Addison to get rolling in the same game.
Drake London's breakout should continue against a Seattle secondary that might be without its two starting boundary corners.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.
The Indianapolis secondary is weakest on the boundary and downfield, where Mike Evans is at his best.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
The Colts' cornerback personnel is weak but their run defense is strong, setting up a feast for Calvin Ridley and the Jags passing game.
Jerry Donabedian looks at the best and worst matchups of Week 1, including WR Mike Evans facing untested cornerbacks in Minnesota.