Deebo Samuel could go nuts as the desperate 49ers take aim at a weak Tampa Bay corner rotation.
Justin Jefferson will almost certainly have a big game Sunday, and the Colts pass defense is weak enough for Jordan Addison to get rolling in the same game.
With Tua Tagovailoa back in the lineup Jaylen Waddle should get rolling against Arizona, and the same is true of Tyreek Hill if he plays through his foot injury.
Drake London's breakout should continue against a Seattle secondary that might be without its two starting boundary corners.
The showdown between Detroit and Dallas could set up a punch-for-punch heavyweight contest where CeeDee Lamb and Amon-Ra St. Brown both go off.
Michael Pittman got back on track in Week 4 and should keep it rolling in Week 5, as neither the Jags nor Colts have viable coverage personnel.
George Pickens should get going against an Indianapolis defense with questionable boundary personnel
Amon-Ra St. Brown will likely torch a thin Buccaneers secondary playing without its star enforcer in Antoine Winfield.
The Carolina Panthers' win total is set at 5.5 this season and Jim Coventry has the breakdown on whether Bryce Young and Co. can turn things around.
Trevor Lawrence finally suffered an injury he can't play through, with the Jaguars officially ruling him out for Week 17.
CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
James Cook struggled against the Chargers on Saturday, but he dominated Buffalo's backfield snaps and touches to an extent previously unseen this season.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.
The Indianapolis secondary is weakest on the boundary and downfield, where Mike Evans is at his best.
Playing at home and against the Bears, the Week 11 setup couldn't be much easier for Amon-Ra St. Brown.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
Christian Kirk should maintain momentum against a Houston defense without two of its top three corners, including their slot defender.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.