Louisville
31.0 Pts
Pittsburgh
26.5 Pts
Saturday September 27, 2025 at 12:00 PM ET
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Moneyline
DraftKings DraftKings
-198
PROBABILITY with vig removed
Lou Cardinals Win (-198)
63.7%
Pitt Panthers Win (+164)
36.3%
LINE MOVEMENT
Spread
DraftKings DraftKings
-4.5
PROBABILITY with vig removed
Lou Win By 5+ Pts(-108)
49.6%
Pitt Win or Lose By < 5 Pts(-112)
50.4%
LINE MOVEMENT
Over Under
DraftKings DraftKings
57.5
Points
PROBABILITY with vig removed
Over 58 Total Points(-110)
50.0%
Under 58 Total Points(-110)
50.0%
LINE MOVEMENT
Lou
Cardinals Injury Report
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Pitt
Panthers Injury Report
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Lou
Cardinals News
#3 WR
Dacari Collins: Solid outing vs. BGSU
Sep 22nd
Collins gathered in all four targets for 84 yards during Saturday's 40-17 victory against Bowling Green.
#2 WR
Caullin Lacy: Nears 100 yards in Week 4
Sep 22nd
Lacy gathered in 8 of 11 targets for 97 yards during Saturday's 40-17 victory over Bowling Green.
#3 RB
Keyjuan Brown: Plays well in other Brown's absence
Sep 22nd
Brown logged 12 carries for 84 yards and two touchdowns and gathered in all two targets for 35 yards during Saturday's 40-17 win versus Bowling Green.
#1 QB
Miller Moss: Can't find end zone in win
Sep 22nd
Moss was 23-for-32 passing for 316 yards during Saturday's 40-17 victory versus Bowling Green.
#1 RB
Isaac Brown: Dealing with lower leg injury
Sep 22nd
Brown (undisclosed) suffered a lower leg injury against Bowling Green and his availability for Week 5 against Pittsburgh remains up in the air, per Jody Demling of 247Sports.com.
#2 RB
Duke Watson: Lower-leg injury affecting status
Sep 22nd
Watson is questionable for Saturday's game at Pittsburgh because of a lower-leg injury, Jody Demling of 247Sports reports.
#4 RB
Jamarice Wilder: Sees four carries in debut
Sep 21st
Wilder (undisclosed) notched four rushes for 15 yards during Saturday's 40-17 victory against Bowling Green.
#1 TE
Nate Kurisky: Suits up but minimally invovled
Sep 21st
Kurisky (hand) caught their only target for negative three yards during Saturday's 40-17 victory over Bowling Green.
#1 WR
Chris Bell: Nicked up Saturday
Sep 21st
Bell (undisclosed) was nicked up in Saturday's win over Bowling Green, per Jody Demling of 247sports.
Pitt
Panthers News
#1 RB
Desmond Reid: Practices during bye week
Sep 22nd
Reid (lower body) practiced during Pittsburgh's bye week but his status for Week 5 against Louisville remains unclear, per Justin Guerriero of the Pittsburgh Tribune-Review.
#1 QB
Eli Holstein: Another 300-yard game
Sep 15th
Holstein was 22-for-37 passing for 303 yards, one touchdown and one interception during Saturday's 31-24 overtime loss versus West Virginia. He also had 14 rushes for -27 yards with one touchdown.
#1 WR
Raphael Williams: Another stellar outing
Sep 15th
Williams posted six receptions (on nine targets) for 119 yards and one touchdown during Saturday's 31-24 overtime defeat to West Virginia.
#8 WR
Bryce Yates: Hauls in long catch
Sep 15th
Yates gathered in all two targets for 74 yards during Saturday's 31-24 overtime defeat to West Virginia.
#1 TE
Jake Overman: Sitting out after all
Sep 13th
Overman will not play in Saturday's game versus West Virginia, Justin Guerriero of the Pittsburgh Tribune-Review reports.
#3 WR
Censere Lee: Out at West Virginia
Sep 13th
Lee (undisclosed) is out for Saturday's game at West Virginia, Stephen Thompson of the Pittsburgh Post-Gazette reports.